Targeting HER2 in other tumor types
نویسندگان
چکیده
منابع مشابه
HER2 Targeting Peptides Screening and Applications in Tumor Imaging and Drug Delivery
Herein, computational-aided one-bead-one-compound (OBOC) peptide library design combined with in situ single-bead sequencing microarray methods were successfully applied in screening peptides targeting at human epidermal growth factor receptor-2 (HER2), a biomarker of human breast cancer. As a result, 72 novel peptides clustered into three sequence motifs which are PYL***NP, YYL***NP and PPL***...
متن کاملBispecific minibodies targeting HER2/neu and CD16 exhibit improved tumor lysis when placed in a divalent tumor antigen binding format.
Unconjugated monoclonal antibodies have emerged as important therapeutic agents for selected malignancies. One mechanism by which antibodies can exert cytotoxic effects is antibody-dependent cellular cytotoxicity (ADCC). In an effort to increase the efficiency of ADCC at tumor sites, we have focused on the construction of bispecific antibodies specific for the tumor antigen HER2/neu and the Fc ...
متن کاملTargeting HER2: precision oncology for colorectal cancer.
www.thelancet.com/oncology Vol 17 June 2016 685 Advanced colorectal cancer still has a poor prognosis and more active drugs are urgently needed. HER2 was investi gated as a target in colorectal cancer in two early trials of trastuzumab plus chemotherapy as fi rst, second or third line therapy, which produced interesting but confl icting results. In The Lancet Oncology, Andrea Sartore-Bianchi an...
متن کاملCharacterization of a Novel Transgenic Mouse Tumor Model for Targeting HER2+ Cancer Stem Cells
HER2 is an oncogenic tumor-associated antigen overexpressed in 20-25% of breast cancers, which is associated with increased invasion, metastasis of the disease and resistance to therapy. Recent studies have further shown that HER2 can increase the population of breast cancer stem cells (BCSCs). However, there is currently no in vivo model for the study of HER2(+) BCSCs. In this study, we charac...
متن کاملPolyclonal Antibody against Different Extracellular Subdomains of HER2 Induces Tumor Growth Inhibition in vitro
Background: Human epidermal growth factor receptor 2 (HER2) has a crucial role in several malignancies. The extracellular domain of HER2 (HER2-ECD) has been extensively employed as an important target in passive and active immunotherapy. Isolated recombinant prokaryotic HER2-ECD subdomains were previously found to be ineffective in inducing anti-tumor antibody response. Objective: To employ rec...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2001
ISSN: 0923-7534
DOI: 10.1093/annonc/12.suppl_1.s81